The main thing I noticed was that the trailer showed scenes that I remember came directly from the original game (eg. the burning truck)
Watching Resident Evil 2 being played was traumatic for me when I was a small child. I was frightened of large windows at night-time for a long time, if anybody knows the area in the game I'm referencing. Nowadays I don't mind watching the series being played, but I just don't feel comfortable playing it =P
Regardless, it's a good-looking game. There are promises of more backstory, which is always good.