Jeph, I know the comic helps. And nothing gets you over the "I'm not worthy" feeling than getting something out there that is really worthy!
This strip may not have been what you had in mind (how often are they?), but a side trip into AnthroPC humor is always welcome, and doesn't really happen often enough. And this trip was... well... trippy!
You might want to talk to someone (a professional) about SAD, Seasonal Affective Disorder. I know you're on meds, but sometimes things get thrown out of whack by your environment. I know that fall has a weird (negative) affect on me, since I was a kid. Sleeplessness, a general panicky feeling, depression, and a few other symptoms that sound a little like what you're going through. I got through it in the 70's-80's through psychotherapy (before there were meds), and my daughter and I now use light therapy. It can work!
Remember, fall doesn't suck, and neither do you!