The setting is great, the music that goes with that setting is even better. My roommate actually came over "Dude what are you playing? Is this Dragon Age? Because this is some epic quasi-mystical musi... this is Far Cry?"
Very rich characters and world. Pagan Minh is imho a better and scarier villain then Vas ever was... and there's lots of moral ambiguity in all the factions. The moral choices, actual moral choices mind you, with no "good vs. evil meter" sliding back and forth to tell you if you've been naughty, in the main story campaign missions, or rather which of the two rebel faction leader's missions you follow actually have some weight to them.
For example a mission to Pagan Minh's heroin operation can consist of securing the supplies and operation for the Golden Path, vital to supplies and in Leader 1's opinion Kryat's immediate future because of their lack of industrial base, or you can destroy the facility for it's perversion of Kryat. What's the right thing to do? I can't say myself.