I just saw the premiere. I haven't read the comic in so long that my memory is a bit hazy, so I'm less inclined to nit-pick at the differences. I did quite enjoy it, as both the pacing and casting were spot-on.
Obviously the language had to be toned-down quite a bit. The violence is there, with a few hilarious antics from Cassidy especially. The episode basically introduced the main cast, got them in the same place with Genesis being this "thing" exploding a number of religious people over the world until the end.
Anyone watching season two? Also, I still have no idea why hedgie and BK dislike Seth Rogen.
They changed the Saint's origin, but I still dig it.