I don't know if you guys would consider Harvest Moon games some of the best out there(I know I do), but seriously... how do you beat them?! I've played all of them, and the only one I've gotten close to beating was Another Wonderful Life, and I still have like... 5 game years left.
But yeah, onto less of HM, I never managed to beat any of the Geneforge games. I tried, and I got SO close to beating GF: 2, but I never did. I got stuck on some random room where giant spikes from the ground would attack me with blasts of angry light when I'd walk in. It made me sad.