After rereading my first post, let me see if I can articulate this better.
I don't think that making a game that is commercially viable in the modern sense of the retail market and full-time development studios and making a game out of love for the medium and confidence in what you're doing are mutually exclusive categories. If you're going to tell me that Super Mario Galaxy, a game with a (relatively) large budget and a fantastically high amount of copies sold even 4 months after its release, is made by people who don't have love for the medium, I will tell you that you are out of your fucking mind. I think that Blow is reacting to this new trend that many independent developers are making their games and shopping them at IGF or online or through other channels hoping to get picked up by a full-time studio. But that's essentially what gave us Portal: the Digipen students brought Narbacular Drop to Valve and Newell hired them on the spot. That has become the dream goal for a lot of these people who are essentially designing games in small groups during their free time, and Blow, presumably out of disenchantment with the current development model, believes that makes their products less creative or artistic because they're made with the goal of getting them hired into the 'establishment', as it were. Hopefully, it goes without saying that that is a load of crap. I don't think your delivery model makes your ideas inherently better or worse. Are concessions made to make a game more likely to sell? Absolutely, there's no denying that it happens all the time. But that doesn't prevent games with creative ideas from selling well all the time.
No matter how you look at it, Blow is being pretentious. I don't know what he does that he can afford to make games that don't sell, but clearly not everyone can do whatever it is, so he might need to stop running his mouth. In fact, you could even insinuate that Blow is being fairly hypocritical, since Braid is coming to Xbox Live Arcade, which Microsoft is the sole gatekeeper for and is for better or for worse a very closed system.