There are two games I'm anticipating before the end of the year. One of them is the expansion to Neverwinter Nights 2, entitled Mask of the Betrayer, and the other is Mass Effect.
MotB picks up the (pretty weak, I thought) story of NWN2 in the Rashemen region of the Forgotten Realms. That's the homeland of Minsc from Baldur's Gate 2. The developers have been name-dropping Planescape:Torment quite a bit, in reference to NPC depth and player choice, but I'm skeptical. Obsidian Entertainment, composed mostly of refugees from Black Isle, hasn't really challenged itself yet, instead opting for discarded Bioware sequels. I'm awaiting it just because solid western RPGs of any kind are hard to come by these days.
As for Mass Effect, I probably should be anticipating it more, but Jade Empire was a big letdown, and it seems like the quality of Bioware's product has been in gradual decline since Baldur's Gate 2 in regard to their characters and storylines (technically, there's been an even more severe drop in player choice since Baldur's Gate, up until Jade Empire, which felt like a JRPG) but I'm optimistic, and I like sci-fi, though I'm more of an Alien guy than an Aliens guy. For some reason what's been released so far really reminds me of Halo, and that's not encouraging.