Stephen Maturin and Jack Aubrey from the Patrick O'Brian novels (they were okay in the movie, but frankly not nearly as awesome, especially Stephen).
I mean, Stephen is a world-renowned scientist, amazing (perhaps House-like) Doctor, accomplished duellist, wildly adventurous pharmocological self-experimenter and incredibly able spy. (So no, as cute as womenfolk may have found Paul Bettany, he didn't do him justice).
Jack is a brilliant tactician, oaf, accomplished astronomer and mathematician, surprisingly well-meaning/naive rake and brilliant musician.
BFF.