Mass Effect multiplayer? Well, the first thing I can tell you is that it won't involve Shepard. But remember the multiplayer feature in Bioshock 2? Instead of incorporating the single player experience into a multiplayer game, they added a new backstory and slightly different gameplay to the multiplayer part of the game. In a story-heavy game, this has the advantage of making the individual multiplayer character insignificant to the story, but the whole of the players do matter. So instead of a one-man quest through the perils of Rapture, you play a citizen in the civil war. They could easily do the same with Mass Effect. There is a ton of backstory that gives plenty of opportunities for multiplayer skirmishes. There's the First Contact War, Geth Uprising, Rachni Wars, Krogan Rebellions, and tons of other historical events they can cook up at a moment's notice. Will be interesting.