There are so many questions.
Like, if this is going to be based on the manga, rather than the film, who's going to replace the Americans (who turn up in book three or four and start trying to assassinate Akira and Tetsuo before etc. etc. spoilers etc.)? Is it just going to be...the Americans? Like their own government? Because that changes the plot quite a lot. Like the relationship between the Colonel and the Americans, how is that going to be handled?
I mean, don't get me wrong, the idea of a new adaptation of Akira has some legs. The Manga is a monumental work, six volumes of about five hundred pages each, beautifully drawn and well plotted. The anime film, though excellent (particularly in terms of soundtrack and visual flair) Only really takes the story to the end of the second book (then ranges a few fragments of the third and fourth in) and leaves it all rather mangled, which is a large source of the 'WTF factor'. The story also benefits a lot from the deepened characterisations of people like The Colonel and Joker (who barely even appears and doesn't speak in the film), Lady Miyazako (who also barely appears, as a completely different character), Tetsuo's sinister aide-de-campe, and of course Chiyoko.
But this is going to be shitting dreadful.