I watched Maquia (a recent Japanese animated film). Don't watch it if you're not prepared for a strong weepy (this aspect has put some reviewers off in a serious way)! It's also a somewhat confused story, as there is a main story but with a lot of quite intricate side-stories as well; again, your reaction might depend on how you view these - some reviewers feel the film isn't long enough to do justice to the whole range of characters, and others feel it should be shortened by excising them altogether. Me, I'm happy with the way it is, because the good so strongly outweighs the bad.
An aspect which confused some people is that the film covers a timescale of at least 70 years, with frequent time skips which are not clearly signalled. But this is actually important, because we are being shown the viewpoint of the title character, who has an expected lifespan of hundreds of years and so retains the same teenage appearance throughout while others age around her. The other main character (whose changes show us the time skips) is her "son", whom she rescued from a massacre as a baby and then brought up, often agonising over whether she could really be a mother - the film ends with her, still looking like a teen, visiting him on his deathbed and meeting his grandchild. (The son has several different voice actors as he ages through the film.)
If there is a theme, it's that loss, while sad, shouldn't destroy the memories of happiness. The film is a visual treat, though, and although it's not quite great, it is very well worth watching. The English dub is also very good, fortunately.