I've only seen most of the first season of the show and didn't care for it. Loved the game, though, just finished episode 5. Oh, and Gregorio, re: episode 3
If you convince him to jump he still bounces off and fucks up his leg.
I'd go onto the game wiki after finishing each episode to see the alternate paths and was a little annoyed how most of the choices...ultimately didn't really matter. Spoilers for all the whole thing, btw.
Went to save Duck? Shawn dies. Went to save Shawn? Shawn still dies, and Duck's ok. Went to save Carly/Doug? Lilly shoots the other by the side of the road. Save Ben from falling? He dies the next episode, with Kenny going out trying to save him. Don't save Ben from falling? Kenny apparently still dies somehow. Leave Lilly by the side of the road, never see her again. Take pity on her, bring her with you...she ends up running off anyway. Cut off your arm? I was actually fine with you still dying of the bite (since it'd clearly spread already), but it doesn't really stop you from doing anything. And a few more, probably.
Yes, they're all different scenarios, sure, and it's more choice than most choice-based games, but it still kind of bugged me a little.