Seriously. I don't want to go on recommending a font people hate so horribly. Tell me something else - ANYTHING else - that meets universal-use conditions as well as comic sans does.
Arial.
I would say Helvetica.
And I would say that neither of those looks anything like hand-lettering.
I do, however, regularly recommend Helvetica if resemblance to hand-lettering isn't specifically required.
A really horribly bad version of Arial (which appears about 20% smaller) was, at least up to last year, installed by default on a lot of Linux machines and makes anything in Arial nearly unreadable to some fraction of browsers.
I wasn't replying in that regard. They are nearly identical fonts as one is basically a carbon copy of the other. I was just pointing out to Zebediah that Helvetica is the OG.
To be fair, you did say "universal-use," which Helvetica definitely hits. Legibility, a thousand weights, and timelessness.
If you're talking
approachability... As far as handwriting fonts (or comic book lettering, as Comic Sans was created to mimic), I could name a few (Good Dog, mostly known for being used in the "Keep Austin Weird" slogan, and Chalkboard and Kristen are also classics from the PC), but of course they do not have the ubiquity of Comic Sans. Comic Sans has been a native font on PCs for over 20 years and has been the butt of tired graphic designer jokes for about that long. Hard to beat it.
I could nerd out about typefaces forever, so I'll stop now.