Besides those two breakups, what else is there? Marten/Padma, a couple of Steve's (does Sara count? Ellen, Tortura the Russian spy, and Meera IIRC) and Nat/Amir. Faye and Sven doesn't really count, does it?
And The Talk was unambiguous to me, JJ even called it The Talk (see strips 500 to 509, conveniently titled The Talk, Part 1 through 10).