I do rather hope that if Claire the job Marten goes with her. Not that I dislike either character, but they're both pretty much secondary or even tertiary characters at this point. If they get put on a bus, and only appear once in a blue moon (like the Boston crowd in SP), then that gives Jeph more to work with in terms of a smaller cast, or the comic focuses on them in a new environment with new people and would be a sort of reset, where Marten is new somewhere, meeting strange people, and at least this time, a little more mature and a bit happy, sort of how the hero's journey circle goes. The worst scenario in my mind is if she goes alone and they either split up or do the long-distance thing. The latter would involve an even bigger cast, and even less time on known characters.
One thing that I've noticed about my own views of the comic are that I don't tend to get as many laughs at it, because unlike Jeph, I haven't gotten past laughing at dead baby jokes and the like. But over time, I have also become more invested in the characters emotionally, but also then losing some of that connection just because there are so many of them. Trimming the number of people in the ensemble would give those still around more time for their stories.