i've used adblocker plugin, as well as many others like tabbrowser prefrences, disabling targets, downTHEMall (neveractually used), aautomarks, colorzilla, HTML Validator (tidy), and preferential.
As for popups, I don't buy that the internet will "go away" if ads are blocked, Tivo hasn't done that to television, iPods won't drop off the face of the planet the moment somthing better for cheaper comes out, and P2P isn't the end of the music industry
Honestly, the fact that this much goes into blocking ads just means that popups will deteriorate, and in it's place will come RSS ads, or those annoying-as-hell hotlink style ads you see at places like tom's hardware.
Theres no way somthing that has international usage will stop because we hate ads. If anything, it'll just be a bit more expensive to host a server, but with donations and server costs dropping, its not that much of a problem.
The internet is about evolution and change, noone can make us looks at their ads, and frankly I don't want to.