depends on your budget really...
I'm still running a Creative Soundblaster Live, so I can't really comment on the newer cards, except they're not cheap... My cousin had an Audigy 1 and returned it because he said the sound was crap, went back to Live with a partial refund...
I can direct you to some reviews, for the
M-Audio Revolution 7.1 and the
Creative Audigy 2 ZSAs far as speakers go, I CAN personally recommend the Logitech Z-680 system, especially as far as value goes. These should be going fairly cheap just about everywhere, as the superseding model has been released (same power, slightly better controls.) And POWER!!! These have about twice the rated power as the Klipsch speakers, I believe (500w RMS, 1000w Peak Max Power Output.) The sound is unbelievably awesome. Crystal clear, perfect. I have had them up as loud as possible, and while I thought my house would fall down and my ears would run away to hide, there was no sign of distortion whatsoever.
One niggle: I have to have the sub down to almost zero level as it is "too powerful."
Enough raving from me, anyway. I don't have the Klipsch model, so I can't compare directly, but I know the Logitech Z-680 set Rocks. Hard. I bet they'll cost about half as much, too.