Holy crap, how is this even a contest?
Fast paced, constantly hilarious, constantly original, improvisational, character/dialogue-driven comedy gold...
vs.
Boring sitcom-ish tripe.
Home Movies is (was) pretty much one of the greatest comedic works in any medium. If you wanted a question that could conceivably have more than one answer, you'd put it up against the only other show on Adult Swim ever to compete in the same league: Venture Brothers. Even then I'd still give the edge to Home Movies.