Katie, are you applying for all the same sorts of jobs? Maybe you are over/under qualified? Anyway, everyone knows that it really doesn't matter how suited for the job you are, what matters is that you know someone who works there already.
Most of the ones I have applied for are lab assistants, retail (everything from JoAnn ETC, where I worked before, to Hot Topic and Macy's and JC Penny), stocking and restocking (also retail), cashiers, grocery baggers, office assistants, personal assistants, Star Bucks, Border's, Barnes & Noble, and tech support. I can't get manager positions or anything above entry-level because of lack of experience, and I do not have a degree for anything more "professional". I'm almost desperate enough to go back to summer camp jobs. Pretty much the only place left for me to apply is like McDonald's.
I am mostly blaming the area, because it is a college town and so everyone already has student employees.