I think it's probably going to be like any other comic that has undergone a somewhat major art change (e.g; Scary Go Round and it's various transitions between computer-drawn to hand-drawn and back and forth) in that it'll be weird and disliked by a great deal of people for a while, and then you'll get used to it, and then you'll wonder how you ever read it not in colour.
Plus, Carly Monardo is SUPER freakin' talented.