I know this is cliche, but Adult Swim comedy was better back in the day when there was Home Movies, Brak Show, SGC2C, Harvey Birdman, and ATHF that didn't suck.
Sure, Venture Brothers is great and Tim and Eric and Metalocalypse have their moments, but that doesn't make up for the several terrible shows that have been aired in the past few years. Morel Orel, Squidbillies, Xavier, Assy McGee, TG2TM, Fat Guy Stuck in Internet, Saul of the Molemen, and 12 oz Mouse are all terrible, awful shows that should never have been broadcast. Ever.
Side note, though. I am looking forward to Superjail