Well, basically yeah, everything sounds good when your high, but for my money/buzz the best things to listen to when fucked up on ____ are as follow, IMHO:
Weed: Explosions in the Sky (Post rock in general is for being high, duhz), DJ Shadow, Immortal Technique/Tonedef (Together here because it's for the same reason), all my indie rock faves, even including Modest Mouse and NMH, who are by now too famous to be indie (or maybe I don't even know what that means.)
Psychedelics: Dubbity dub step, Drum & Bass, a la' Fabric/Fabriclive, and I had one of the best shroom trips ever ever ever listening to TOOL, so there you go. I also love to zone out to American Traditionalist guitar and Banjo.
I don't do uppers so I dunno, and I can confirm everything I listed is totally awesome Sober as well, but really, if you take your 5 favorite bands and make a good mix cd with all your favorite songs, i fail to see how this won't enhance any drug experience you're currently grooving too (See also: Bring your iPod everywhere when high).