On thing that may help on the format front... instead of the comic image being one giant panel, each frame gets its own container. Then, depending on screen size, the comic frames either go 2 x2 like they are now, or for smaller screens, get stacked in a 1 x 4. All of this is relatively easy to do with a bit o' CSS targeted at a few different screen size breakpoints using media queries.
Just a thought from a web geek.