Dealing with a "bigoted religious relatives" arc would be difficult for me, but sometimes good art is difficult, and sometimes difficult helps us get past things that have been hanging over us.
I had a cousin who died of HIV. Family relationships and bigoted relatives were among the reasons he never sought treatment. It was about whether he'd be allowed to be buried on the family plot in Hallowed Ground.
So... he lasted a couple of years and died a horrible painful lingering death, which is the way of HIV left untreated. By his own choice ultimately, to go along with my aunt and uncle's judgment on the matter. I think I may be the only one he ever talked to about it, because I'm the one who recognized the AIDS symptoms and said so, in private, when I was trying to get him to go to the doctor.
I haven't spoken to that particular aunt and uncle in the last decade, and probably won't. They may be family, but they're family I don't want to be around anymore.
So, yeah, a "bigoted religious relatives" arc would be depressing for me. Then again, I could appreciate it as a statement too, and would be interested to see where Jeph took it.
All I'm going to say about this question is, 'Trust the Artist to Make the Art.'