First off, I would like to say hi to everyone, as this is my first time posting. I have been lurking in the forums for a good 7+ years or so, and a reader on the comic since about then (give or take).
Now, on to my post:
I'd say she either is Autistic, or she has other issues that she deals with much like Hanners sometimes does by having a routine she doesn't like deviating from and cause her anxiety and stress.
It does seem likely that she would either be Autistic, Savant, or have an yet unnamed social or anxiety disorder. I say that based on the following observations:
1). The lack of obvious panic of having been in a fire, and subsequent loss of all personal belongings and safe space in said fire.
2). When she became overwhelmed finally and was unable to speak (a possible fugue state).
3). The seemingly overprotective (and seemingly over reactive ) friend on the phone.
4). Forgetting basic "things" when routine is disrupted (shower being in hotel room, renter's insurance, etc. al).
5). Admitting to an emotion disconnect (#3222).
6). Initial rough greeting (possibly due to the line of work, and that Clinton is not a regular)
Admittedly, all of these seems circumstantial, even when placed together. However, considering my former girlfriend at one time exhibited these very same emotions (she worked at a Waffle House on 3rd shift no less), just by my experience alone leads me to belive that she, at the very least, has a social disorder of some type.
Having said that, i hope Jeph keeps her as, at least, a semi-regular member of the cast.