I don't think there's anything to be read into it besides the fact that Jeph has more female characters. When it comes down to the min cast, there are only two male AI, Pintsize and Winslow. Pintsize has been perving on everyone since the start, and Winslow is the innocent. On the other side we have Momo, May, Bubbles and maybe Roko. Depends on if she keeps getting comics featuring her. So in the main cast we have to male AI, both of which are not really candidates for cross-species romance, and 3/4 female AI, all of which have fantisized or expressed direct interest in humans. So it's pretty clear that when Jeph explored the idea it was going to be involving one of the female AI.
Also this is not the first time it was cross species romance was mentioned in comic. In one of the robot support group strips one of the robots was talking about an issue with their girlfriend probably wanting to date a human. Implication being the the girlfriend was human and the AI was insecure about it, or the girlfriend was AI and interested in humans. Nobody seemed to think it was unusual though. And there was the Robo-boyfriend Hanner's dad sent her to try out. We may not have seen an AI/Human romance in print yet, but it doesn't seem to be surprising, which implies it happens.