Alright, I read the whole thing.
***SPOILERS BROHEM***
Good
Deadpool is spot on the sardonic, insane, violent asshole he should be. Enjoyable.
The minor characters are a little irrelevant and memorably insane. Also enjoyable.
Throwing in Colossus as the straight man is fantastic since Cable would require three movies worth of exposition to even begin to explain.
When the topical humor and references hit, it's really good. Especially the seething hatred for X-Men Origins: Wolverine that drips from this script.
Neutral
The obvious hard R. Ultra violent, sex, language. It doesn't pull punches and a small part of me wonders if that's the best course of action. I think it would be fantastic if it were censored down to PG-13 in the most hamfisted, obvious way possible, like...basic cable censorship level. ("This is what happens when you find a stranger in the alps!" "Yippee-ki-yay Mister Falcon!") I'm not opposed to it in its current form either though.
Bad
When the topical humor and references miss, it's Family Guy or, worse, a Wayans Bros. movie. The constant Amy Winehouse callback joke is I think the most obvious example of this. Abusing a celebrity for shits and giggles isn't good comedy. If it were clever, I could be down with it, but it really just stinks of something you'd see in Shitty Movie 3.
Breaking the 4th wall. I feel like the script misses the essence of DP's relationship with the 4th wall. The script has him aware of the audience, which isn't particularly clever and is a pretty ancient trope. I mean, pausing time to talk to the audience is some Zach Morris shit. Deadpool is more aware of the comic book than the audience and that needs to be the direction they take. Awareness of the movie. Talking to the director mid-shot. Mockiing bad acting. Playing with the subtitles.
**END SPOILERS BRAH***
Ultimately, though, it was an eminently enjoyable script anyhow. I'd love to watch this movie.