I think we should all brace for impact. Especially considering that tomorrow's comic is 2800.
Just from experience, Jeph does like have the major stories around the X00th comics, if not starting there at least the crux of the story happens at that point; such as the Talk at 500, the Break-Up at 1800, Padma leaving at 2100, the beginning of May's redemption at 2500 (and in turn, the beginning of Dale & Marigold growing up and talking like relatively normal people).
There are quite a few character storylines beginning on the X00th comics and I suspect this will be no different.