Those are things to feel sad and unhappy about, which is different from the malignant nothingness of depression that Allie Brosh explained so well at Hyperbole and a Half.
No you can get a full depression from it, and people suicide because of such things.
Like for example the author of Conan the barbarian, Robert Ervin Howard, couldnt take it that his mother had died.
Another example is PTSD that for example rape victims, prostitutes and soldiers who experienced war can get.
[...] For some reason, Bubbles' face seems subtly 'off model' in this strip. Is it just me or does anyone else see it too?
Artstyle changes all the time ... n ot so much recently anymore, sure, but a bit of variation is to be expected.
And I dont see it, sorry.