Well, Capcom has talked about before how every single character in Street Fighter IV costs at least $1 million to make and release. This isn't even going into other aspects of the game, just developing the movesets and animations. I know the developers of Skullgirls, an indy fighter title, released their development costs for a IndiGogo campaign to raise money for an expansion DLC and it was around $200k per character even for them.
Something like Mass Effect might be a little skewed due to sharing of assets between games too, but I'm pretty sure Bioware has never shared development costs before. I don't think Bethesda has ever released any of their development costs for their projects either, but I assume it was pretty ridiculous, if not anywhere near as close to this, as well. Though clearly none of that money goes into their writing team.
Edit: I'm seeing rumors of $60 mil for Skyrim, but nothing that confirms it. Can't find a damn thing for the ME series. I mean, there are also MMOs that blow $200 mil out of the water, but I don't think they're a fair thing to use in comparison considering how much of a different beast AAA MMO development is.